![]() The use of DNA analysis to improve the performance of soccer players. praziquantel silymarin hepatoprotective colorimetric assay Keywords: Schistosoma mansoni Capparis spinosa L. in chronic liver diseases may shed light on developing therapeutic methods in clinical practice. Nevertheless further studies on the mechanism of action of C. ![]() has a promising hepatoprotective and antifi brotic properties and could be introduced as a safe and effective therapeutic tool with PZQ in the treatment of schistosomal liver fi brosis. spinosa L.leaves contain higher concentration of polyphenolic compounds than fruits. Quantitative estimation of total polyphenols content using colorimetric assay showed that C. ![]() The best results were obtained in the group of mice treated with C. caused a partial decrease in worm burden a statistically signifi cant reduction in hepatic and intestinal tissue egg load, what was associated histopathologically with decreasing in both the number and diameter of granulomas, as well as restoring serum aminotransferases (AST & ALT), alkaline phosphatase (ALP) and improving liver albumin synthesis. Total polyphenols in the extract were determined using colorimetric assay. spinosa) with or without praziquantel (PZQ) and compare results with silymarin (Milk thistle), a known hepatoprotective and antifi brotic agent, on induced liver fi brosis by experimental Schistosoma mansoni (S. The present study was designed to investigate the potential complementary schistosomicidal and hepatoprotective activities of the methanol extract of Capparis spinosa L. Therefore, treatment targeting hepatic fi brosis associated with schistosomiasis remains a challenging proposition. Though chemotherapy eradicates matured worms effi ciently and prevents the accumulation of schistosome eggs, fewer effective drugs are directed to reverse the present hepatic fi brosis. Schistosomiasis remains to be the most common fi brotic disease resulting from infl ammation and deposition of scar tissue around trapped parasitic eggs in the liver. ![]()
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